Tissue Microarray Solutions

Explore Tissue Microarray Technology with TMA Grand Master, TMA molmed, and TMA Master II – three high-performance instruments designed for precision, efficiency, and high-throughput sample processing. These solutions empower molecular pathology, translational research, and biobanking by enabling automated, high-density TMA block creation with advanced digital integration.

Tissue Microarrays

Tissue Microarray Solutions for High-Throughput Research and Molecular Pathology

Tissue Microarrays are an innovative approach to histopathological analysis, enabling high-throughput, multiplexed tissue sample studies on a single slide. By extracting precise tissue cores from multiple donor blocks and embedding them into a single recipient block, TMAs streamline workflows, enhance reproducibility, and maximize sample efficiency for research in pathology, oncology, and molecular diagnostics.

With TMA technology, laboratories can efficiently process large sample cohorts, reducing reagent costs and slide preparation time while maintaining high-quality histological integrity. TMAs play a crucial role in biomarker discovery, drug development, and personalized medicine, supporting IHC, FISH, and molecular profiling techniques.

Key Features:

TMA Grand Master – Fully Automated High-Throughput TMA System

The TMA Grand Master is the ultimate high-capacity, fully automated TMA instrument, capable of handling ultra-high-density TMA blocks with unmatched speed and precision. Designed for large-scale research projects, it ensures seamless core transfer, digital integration, and advanced barcode tracking for an optimized workflow. Tailored for institutional research applications, includes an All-in-one Server PC and TMA Control software.

TMA molmed – Modular Precision for TMA Creation & Molecular Sampling

TMA molmed combines TMA preparation with molecular sampling, making it ideal for translational research, PCR workflows, and biomarker discovery. With mega block compatibility, this dual-functionality instrument enables high-volume sample processing, supporting up to six standard donor blocks or two mega blocks with 30 PCR tubes, as well as configurations for three standard donor blocks or one mega block with a wellplate. Its open modular architecture supports PCR cassettes, microtiter plates, and customized tissue cassettes, ensuring seamless integration into molecular workflows for DNA, RNA, and protein extraction, including PCR, dPCR, and sequencing applications, ensuring precise and contamination-free processing. TMA molmed also offers seamless MRXS digital slide integration. Offered as a solution package for small to medium laboratories with a control PC, TMA-specific software and complimentary 3DHISTECH research software.

TMA Master II – Automated TMA Production for Research & Pathology

The TMA Master II delivers automated tissue core extraction and placement, offering customizable recipient block layouts and high-throughput TMA creation. Designed for medium-to-high sample volumes, it provides intuitive software control, precise core alignment, and flexible tissue sampling options. Offered as a solution package for small to medium laboratories with a control PC, display monitor and Software – TMA Control, SlideViewer & SlideMaster.

Optimize your research with our TMA Solutions

High-throughput automation – Process hundreds of tissue cores per hour

Modular & customizable – Configure core sizes, layouts, and sampling workflows (molmed)

Digital integration – Supports MRXS digital slides, barcode tracking & multi-format exports

Ideal for molecular research – Compatible with IHC, FISH, PCR, and sequencing applications

Contamination-free sampling – Automated handling for PCR tubes and wellplates

TMA Research Use Cases

Tissue Microarrays (TMAs) are highly valuable for high-throughput histological and molecular analysis, enabling biomarker discovery, drug testing, and disease research across multiple scientific disciplines.

Below are the research applications and use cases where TMAs are applicable:

Research
For human

Biomedical Research

Biomedical research is experiencing a major shift with the integration of Digital Pathology and Micro-CT solutions, significantly improving tissue analysis, biomarker discovery, and disease modeling. Traditional microscopy methods have inherent limitations, such…

Research
For human

Cancer Research

Cancer research demands cutting-edge imaging technologies to enhance biomarker discovery, tumor profiling, and immuno-oncology advancements. Traditional histopathology techniques, while fundamental, present challenges such as limited scalability, subjective interpretation, and data fragmentation. Digital…

Research
For human

Genetics

Genetic research demands precise imaging tools capable of capturing high-resolution cellular and molecular structures for in-depth analysis. 3DHISTECH’s Solutions for digital pathology supported by QuantCenter, QuantServer, SlideManager, and SlideCenter, provide an AI-driven,…

Research
For human

Immunology and Infectious Disease

Immunology and infectious disease research require precise cellular analysis, biomarker quantification, and advanced multiplex imaging to understand immune responses, pathogen-host interactions, and disease progression. Traditional histopathology methods are labor-intensive, slow, and prone…

Research
For human

Molecular Cell Biology

Molecular cell biology research relies on high-resolution imaging and fluorescence capabilities to analyze cellular structures, molecular markers, and complex biological interactions. The integration of digital pathology solutions from 3DHISTECH—Pannoramic Confocal, Pannoramic 250…

Research
For human

Pharmacology

Pharmacology research is essential for drug discovery, preclinical evaluation, and biomarker validation. However, researchers face significant challenges in high-throughput tissue analysis, biomarker quantification, and data integration. Traditional microscopy and manual pathology workflows…

Research
For human

Toxicology

Toxicology research is essential for understanding the effects of drugs, chemicals, and environmental pollutants on biological systems. Traditionally, toxicology studies rely on manual histological evaluation, which can be time-consuming, prone to subjectivity,…

Research
Non-human

Veterinary Pathology

Veterinary pathology plays a vital role in animal disease research, wildlife conservation, livestock farming, and food safety. As disease outbreaks, environmental changes, and food security challenges rise, digital pathology, AI-driven analysis, and…

Solution Components

Hardware Included

Any 3DHISTECH Tissue Microarray

With TMA technology, laboratories can efficiently process large sample cohorts, reducing reagent costs and slide preparation time while maintaining high-quality histological integrity.

All-in-One Server PC / Control PC

A robust and centralized server solution, this component delivers high-performance local and server storage, database management, and processing capabilities. It ensures seamless data handling, maintaining operational efficiency while guaranteeing the integrity and security of your digital pathology data.

Research

TMA Master II

As the smallest fully automated tissue microarray system on the market, the TMA Master II optimizes laboratory space without compromising performance. Its compact footprint allows integration into any lab environment, enhancing workflow efficiency. Advanced automation ensures precise tool size and block height measurements, enabling reproducible array construction. With the capability to generate up to four identical TMA blocks and a dedicated PCR cassette for streamlined molecular analysis, it surpasses conventional systems by combining superior accuracy, reliability, and space efficiency for high-throughput research applications.

Research

TMA Grand Master

The TMA Grand Master automates tissue microarray creation with exceptional speed, precision, and reliability. Designed for high-throughput institutions, it ensures accurate core selection and placement, reducing manual effort while increasing reproducibility. With advanced features and intuitive operation, it outperforms traditional methods and competing systems in efficiency and consistency, making it the ultimate tool for institutional pathology labs, biobanks, large research centers, and pharmaceutical companies.

Research

TMA molmed

Discover the TMA molmed, a fully automated, high-speed solution for tissue microarray creation and molecular sampling from FFPE and mega blocks. Combing precision microarraying with laser microdissection-like functionality, it enables highly accurate tissue extraction for advanced molecular applications, making it an essential tool for pathology, biobanking, and traslational research.

Software Included

TMA Control

TMA Control is the central software for managing all 3DHISTECH tissue microarray (TMA) instruments, facilitating TMA block design and construction with precision. It supports donor block ID and data import from various spreadsheet formats, streamlining workflow integration.

The software features digital slide overlay, allowing for accurate tissue core selection by superimposing annotated digital slides (MRXS) and JPEG images onto donor block scans. With its advanced TMA database, all project data is automatically saved, enabling seamless project continuation even after an interruption or system reboot.

TMA Register

TMA Register provides comprehensive management of TMA data, query handling, and slide design planning. It supports data export in multiple spreadsheet formats and offers advanced search functionalities for retrieving TMA and tissue sample-related information.

Additionally, it facilitates TMA block sectioning and staining workflow planning, ensuring an organized experimental process. By integrating with SlideCenter, TMA Register verifies whether planned TMA slides have been scanned and archived.

Furthermore, stored TMA slides can be automatically de-cored, enabling the generation of individual spot slides for further analysis.

Research Software and Modules

Project Management: SlideManager (5 Users)
Server-Based Storage and Database: SlideCenter (10 Users)
Digital Microscope Software: SlideViewer
3D Viewer Software: 3DView (1 User for 1 workstation)
Web-Based Digital Microscope Software: WebViewer
Portable/Mobile Digital Microscope Software: iPadViewer
Import and Export Tool: SlideMaster (1 Slide Format Conversion License for 1 Workstation)
Image Access Interface: SimpleSlideInterface

Quantification and Image Analysis Modules

Image Analysis: QuantCenter
Server-Based Image Analysis:
QuantServer (16 CPU cores for 3-4 Users)
Image Analysis Algorithm: ScriptQuant

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Service & Support

24/7 Online Remote Maintenance

Round-the-clock remote support ensuring any technical issues are promptly addressed to guarantee the seamless operation of your digital pathology systems throughout the entire warranty period.

Software Upgrade License for 2 Years

Keep your system up to date with the latest software innovations and enhancements, ensuring ongoing performance optimization and feature expansion.

Additional Service & Support

We offer comprehensive integration services with a variety of Laboratory Information Systems (LIS) and Hospital Information Systems (HIS). With a proven track record of successful integrations over the years, we are confident in our ability to seamlessly integrate our solutions with your existing systems.

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Tissue Microarray Solutions