TMA Grand Master

The TMA Grand Master is the fastest, highest capacity and most user friendly tissue microarrayer on the market.

The TMA Grand Master is an automated and sophisticated tissue microarrayer, allowing the precise selection and extraction of specific regions of interest on the donor blocks and their insertion in recipient blocks. The TMA Grand Master elevates the tissue microarray workflow to a new level. With its high capacity, high speed and advanced features it is finally possible to create high density and high quality TMAs in a standardized way. Thanks to the clever hardware design, the block loading, block imaging, and arraying are parallel processes. Therefore, the TMA Grand Master can be loaded with new blocks continuously, even during the arraying process.

The tissue microarray (TMA) technique can be used as a valuable, high-throughput method for diagnostic and research purposes as well. By being able to place up to several hundred different samples into one paraffin block, TMA brings major economies in time quality and costs of tissue preparation, slide preparation and staining. The real advantages of tissue microarrays can only be achieved when using an advanced automated tissue microarrayer such as the TMA Grand Master.

By using TMA Grand Master you can easily and quickly create TMA blocks with great precision, of 0.6, 1, 1.5 and 2 mm diameter tissue cores. Optionally, the instrument can extract tissue samples to standard 0.2 ml PCR tubes. The extracted tissue samples could be used later for various applications at the field of molecular pathology.

TMA Grand Master prepares TMA blocks from biological specimens and samples of human or animal tissues. Typical applications include, but are not limited to the following:

   • Laboratories at hospitals and clinics
   • Pathology departments at hospitals and clinics
   • Biobanks
   • Research centres, in particular cancer research centres
   • Pharmaceutical companies
   • Toxico-pathological laboratories

TMA Grand Master is controlled by the latest version of the TMA Control software. This software is the best solution for TMA block design and creation. It has advanced features for layout design and tissue core selection. A fully automated tool for overlapping an annotated digital slide with the donor block image helps the precise core selection. During the TMA project the software saves automatically all the TMA data, which will be an invaluable resource of information during the TMA slide analysis by TMA Module software.

This easy to use device is one of the most advanced tissue microarrayer on the market with a unique feature set.

Features

- Fully automated control
- High capacity: 72 blocks
  • 60 donor blocks at the same time
  • 12 recipient blocks

- 4 core diameters
  • 0.6 mm (maximum number of cores/TMA block is 558)
  • 1 mm (maximum number of cores/TMA block is 286)
  • 1.5 mm (maximum number of cores/TMA block is 135)
  • 2 mm (maximum number of cores/TMA block is 84))
 
- Fast operation
  • Maximum 12 seconds per core
  • Simultaneous loading, imaging, drilling and punching

- Smart automation
  • Automatic block height measurement to ensure the embedded cores are in alignment with the recipient block surface
  • Automatic barcode reading
  • Automatic donor block and label image saving for reference
  • Automatic project data saving into database

 

 

- PCR extraction function
  • 6 PCR cassettes
  • 10 PCR tubes / cassette
  • use of cleaning block to avoid cross contamination
  • extracted FFPE tissue samples are ready for DNA extraction and PCR analysis with commercially available kits

- Other features
  • Custom recipient block design and production
  • Ability to create up to 12 identical TMA blocks
  • Digital slide overlay for more precise tissue core (sample) selection
  • Ability to import clinical data
  • Ability to export TMA data in various file formats (ods, xls, xlsx, csv, xml)

 

Specification

Capacity, blocks (Recipient and Donor) 72 (12 Recipient and 60 Donor)
Core diameter mm 0.6, 1, 1.5, 2
Maximum number of cores/TMA block 558 (0.6 mm), 286 (1 mm),
135 (1.5 mm), 84 (2 mm)
Speed, core/hour 250-280
Donor block image recording Yes
Use of MRXS digital slide and/or JPEG digital image for sample designation Yes
Barcode reading 1D and 2D
Data export ods, xls, xlsx, csv, xml
Dimensions, cm (W x D x H) 80 x 50 x 46
Weight, kgs 48

 

Product certificates

Product brochure

Recommended reading

TMA Control Software

TMA Module 2.0

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